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Can I read Structure-based design of COX-2 selectivity into flurbiprofen on EtoBox?
Structure-based design of COX-2 selectivity into flurbiprofen by Christopher I. Bayly; W.Cameron Black; Serge Léger; Nathalie Ouimet; Marc Ouellet; M.David Percival is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Structure-based design of COX-2 selectivity into flurbiprofen about?
Comparative computer modeling of the X-ray crystal structures of cyclooxygenase isoforms COX-1 and COX-2 has led to the design of COX-2 selectivity into the nonselective inhibitor flurbiprofen. The COX-2 modeling was based on a postulated binding mode for flurbiprofen and took advantage of a small alcove in the COX-2 active site created by different positions of the Leu384 sidechain between COX-1 and COX-2. The design hypothesis was tested by synthesis and biological assay of a series of flurbiprofen analogs, culminating in the discovery of several inhibitors having up to 78-fold selectivity for COX-2 over COX-1.
Who reads Structure-based design of COX-2 selectivity into flurbiprofen?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Christopher I. Bayly; W.Cameron Black; Serge Léger; Nathalie Ouimet; Marc Ouellet; M.David Percival
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 1999
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)