Opening book details…
Can I read Brain-specific Lipoprotein Receptors Interact with Astrocyte Derived Apolipoprotein and Mediate Neuron-glia Lipid Shuttling on EtoBox?
Brain-specific Lipoprotein Receptors Interact with Astrocyte Derived Apolipoprotein and Mediate Neuron-glia Lipid Shuttling by Jun Yin; Emma Spillman; Ethan S. Cheng; Jacob Short; Yang Chen; Jingce Lei; Mary Gibbs; Justin S. Rosenthal; Chengyu Sheng; Yuki X. Chen; Kelly Veerasammy; Tenzin Choetso; Rinat Abzalimov; Bei Wang; Chun Han; Ye He; Quan Yuan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Brain-specific Lipoprotein Receptors Interact with Astrocyte Derived Apolipoprotein and Mediate Neuron-glia Lipid Shuttling about?
Lipid shuttling between neurons and glia contributes to the development, function, and stress responses of the nervous system. To understand how a neuron acquires its lipid supply from specific lipoproteins and their receptors, we perform combined genetic, transcriptome, and biochemical analyses in the developing __Drosophila__ larval brain. Here we report, the astrocyte-derived secreted lipocalin Glial __Lazarillo__ (GLaz), a homolog of human Apolipoprotein D (APOD), and its neuronal receptor, the brain-specific short isoforms of __Drosophila__ lipophorin receptor 1 (LpR1-short), cooperatively mediate neuron-glia lipid shuttling and support dendrite morphogenesis. The isoform specificity of LpR1 defines its distribution, binding partners, and ability to support proper dendrite growth and synaptic connectivity. By demonstrating physical and functional interactions between GLaz/APOD and LpR1, we elucidate molecular pathways mediating lipid trafficking in the fly brain, and provide in vivo evidence indicating isoform-specific expression of lipoprotein receptors as a key mechanism for regulating cell-type specific lipid recruitment.
Who reads Brain-specific Lipoprotein Receptors Interact with Astrocyte Derived Apolipoprotein and Mediate Neuron-glia Lipid Shuttling?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Jun Yin; Emma Spillman; Ethan S. Cheng; Jacob Short; Yang Chen; Jingce Lei; Mary Gibbs; Justin S. Rosenthal; Chengyu Sheng; Yuki X. Chen; Kelly Veerasammy; Tenzin Choetso; Rinat Abzalimov; Bei Wang; Chun Han; Ye He; Quan Yuan
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)