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Cocaine Locomotor Activation, Sensitization and Place Preference in Six Inbred Strains of Mice by Amy F Eisener-Dorman; Laura Grabowski-Boase; Lisa M Tarantino is a Neuroscience article available to read on EtoBox.

What is Cocaine Locomotor Activation, Sensitization and Place Preference in Six Inbred Strains of Mice about?

## Background The expanding set of genomics tools available for inbred mouse strains has renewed interest in phenotyping larger sets of strains. The present study aims to explore phenotypic variability among six commonly-used inbred mouse strains to both the rewarding and locomotor stimulating effects of cocaine in a place conditioning task, including several strains or substrains that have not yet been characterized for some or all of these behaviors. ## Methods C57BL/6J (B6), BALB/cJ (BALB), C3H/HeJ (C3H), DBA/2J (D2), FVB/NJ (FVB) and 129S1/SvImJ (129) mice were tested for conditioned place preference to 20 mg/kg cocaine. ## Results Place preference was observed in most strains with the exception of D2 and 129. All strains showed a marked increase in locomotor activity in response to cocaine. In BALB mice, however, locomotor activation was context-dependent. Locomotor sensitization to repeated exposure to cocaine was most significant in 129 and D2 mice but was absent in FVB mice. ## Conclusions Genetic correlations suggest that no significant correlation between conditioned place preference, acute locomotor activation, and locomotor sensitization exists among these strains indic

Who reads Cocaine Locomotor Activation, Sensitization and Place Preference in Six Inbred Strains of Mice?

Author

Amy F Eisener-Dorman; Laura Grabowski-Boase; Lisa M Tarantino

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, 2005-; Springer Science and Business Media LLC (ISSN 1744-9081)

Published

2011

Language

EN

Field

Neuroscience (Life Sciences)