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Can I read T-2 toxin metabolism and its hepatotoxicity: New insights on the molecular mechanism and detoxification on EtoBox?
T-2 toxin metabolism and its hepatotoxicity: New insights on the molecular mechanism and detoxification by Wenxi Song; Youshuang Wang; Tingyu Huang; Yu Liu; Fengjuan Chen; Yunhe Chen; Yibao Jiang; Cong Zhang; Xu Yang is a Environmental Science article available to read on EtoBox.
What is T-2 toxin metabolism and its hepatotoxicity: New insights on the molecular mechanism and detoxification about?
T-2 toxin, a type A trichothecene, is a secondary metabolite produced by Fusarium poae, Fusarium sporotrichioides, and Fusarium tricinctum. As the most toxic trichothecenes, T-2 toxin causes severe damage to multiple organs, especially to liver. However, the contamination of T-2 toxin covers a wide range of plants, including nuts, grains, fruits and herbs globally. And due to chemical stability of T-2 toxin, it is difficult to be completely removed from the food and feeds, which poses a great threat to human and animal health. Liver is the major detoxifying organ which also makes it the main target of T-2 toxin. After being absorbed by intestine, the first pass effect will reduce the level of T-2 toxin in blood indicating that liver is the main metabolic site of T-2 toxin in vivo. In this review, updated researches on the hepatotoxicity of T-2 toxin were summarized. The metabolic characteristic of T-2 toxin in vivo was introduced. The main hepatotoxic mechanisms of T-2 toxin are oxidative stress, mitochondrial damage, deoxyribonucleic acid (DNA) methylation, autophagy and apoptosis. The remission of the hepatotoxicity induced by T-2 toxin was also studied in this review followed by
Who reads T-2 toxin metabolism and its hepatotoxicity: New insights on the molecular mechanism and detoxification?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Wenxi Song; Youshuang Wang; Tingyu Huang; Yu Liu; Fengjuan Chen; Yunhe Chen; Yibao Jiang; Cong Zhang; Xu Yang
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Environmental Science (Physical Sciences)