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Biology and Targetability of the Extended Spectrum of PIK3CA Mutations Detected in Breast Carcinoma by Hope S. Rugo; Kira Raskina; Alexa B. Schrock; Russell W. Madison; Ryon P. Graf; Ethan S. Sokol; Smruthy Sivakumar; Jessica K. Lee; Virginia Fisher; Geoffrey R. Oxnard; Hanna Tukachinsky is a Medicine article available to read on EtoBox.
What is Biology and Targetability of the Extended Spectrum of PIK3CA Mutations Detected in Breast Carcinoma about?
## Abstract ## Purpose: Alpelisib is a PI3K alpha (PI3Kα)-selective inhibitor approved for the treatment of hormone receptor–positive/HER2-negative (HR^+^/HER2^−^) __PIK3CA__-mutated advanced breast cancer (ABC) based on the SOLAR-1 trial, which defined 11 substitutions in exons 7, 9, and 20 in __PIK3CA__ (SOLAR1m). We report alpelisib effectiveness for ABC harboring SOLAR1m, as well as other pathogenic __PIK3CA__ mutations (OTHERm) using comprehensive genomic profiling (CGP). ## Experimental Design: A total of 33,977 tissue and 1,587 liquid biopsies were analyzed using hybrid capture–based CGP covering the entire coding sequence of __PIK3CA__. Clinical characteristics and treatment history were available for 10,750 patients with ABC in the deidentified Flatiron Health-Foundation Medicine clinico-genomic database (FH-FMI CGDB). ## Results: __PIK3CA__m were detected in 11,767/33,977 (35%) of tissue biopsies, including 2,300 (7%) samples with OTHERm and no SOLAR1m. Liquid biopsy had 77% sensitivity detecting __PIK3CA__m, increasing to 95% with circulating tumor DNA fraction ≥2%. In patients with HR^+^/HER2^−^ ABC and __PIK3CA__m receiving alpelisib/fulvestrant (ALP+FUL; __n__ = 182)
Who reads Biology and Targetability of the Extended Spectrum of PIK3CA Mutations Detected in Breast Carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hope S. Rugo; Kira Raskina; Alexa B. Schrock; Russell W. Madison; Ryon P. Graf; Ethan S. Sokol; Smruthy Sivakumar; Jessica K. Lee; Virginia Fisher; Geoffrey R. Oxnard; Hanna Tukachinsky
- Publisher
- American Association for Cancer Research
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)