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Brödel et al. have engineered bacteriophages to efficiently deliver gene editors to bacteria in the mouse gut, overcoming challenges associated with genetic modification in complex microbiomes. Their approach utilizes a non-replicative phagemid system to introduce targeted base edits without propagating the genetic cargo, achieving high editing efficiencies in E. coli and Klebsiella pneumoniae. This work represents a significant advancement in microbiome-focused therapies, enabling precise genetic manipulat
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- chuchuchumiya
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- EN