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Alterations in Mast Cells Showing Tryptase and Chymase Activity in Epithelializating and Chronic Wounds by M. Huttunen; M.-L. Aalto; R. J. Harvima; M. Horsmanheimo; I. T. Harvima is a Medicine article available to read on EtoBox.

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**Abstract:** Mast cells can be found in contact with epidermis in certain circumstances; especially in chronic inflammatory skin diseases and chronic ulcers, but the significance of this association is obscure. In this study, the association of mast cells with wound healing was studied by counting mast cells in the wound edges at different stages after wounding the donor site skin for pinch‐grafting. Chronic venous leg ulcers were biopsed for comparison. Tryptase‐ and chymase‐positive mast cells were stained enzyme‐histochemically for active proteinases. Both the number of tryptase‐positive, i.e. total mast cells, and chymase‐positive mast cells decreased during wound healing, __but only the change in chymase‐positive mast cells was statistically significant (P≤0.03) the maximal decrease being 63% on day 7.__ No mast cells could be found in the vicinity of epithelialization margin. In venous leg ulcers, significantly more mast cells were present in the perilesional skin near the epithelium margin than in the wound bed (__P__=0.03), and mast cells were also seen in close contact with the basement membrane. __Immunoreactivity for IL‐4 and TNF‐α in mast cells was studied to see if ei

Who reads Alterations in Mast Cells Showing Tryptase and Chymase Activity in Epithelializating and Chronic Wounds?

Author

M. Huttunen; M.-L. Aalto; R. J. Harvima; M. Horsmanheimo; I. T. Harvima

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0906-6705)

Published

2000

Language

EN

Field

Medicine (Health Sciences)