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Do Early Relapses Predict the Risk of Long‐Term Relapsing Disease in an Adult and Paediatric Cohort with MOGAD? by Bo Chen; Enrique Gomez‐Figueroa; Vyanka Redenbaugh; Anna Francis; Chanjira Satukijchai; Yan Wu; Silvia Messina; Mario Sa; Mark Woodhall; Neil P. Robertson; Ming Lim; Evangeline Wassmer; Rachel Kneen; Saif Huda; Camilla Blain; Christopher Halfpenny; Cheryl Hemingway; Eoin O'Sullivan; Jeremy Hobart; Leonora K. Fisniku; Roswell J. Martin; Ruth Dobson; Sarah A. Cooper; Victoria Williams; Patrick Waters; John J. Chen; Sean J. Pittock; Sithara Ramdas; Maria Isabel Leite; Eoin P. Flanagan; Ruth Geraldes; Jacqueline Palace is a Medicine article available to read on EtoBox.

What is Do Early Relapses Predict the Risk of Long‐Term Relapsing Disease in an Adult and Paediatric Cohort with MOGAD? about?

## Objective Myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD) can be monophasic or relapsing, with early relapse being a feature. However, the relevance of early relapse on longer‐term relapse risk is unknown. Here, we investigate whether early relapses increase longer‐term relapse risk in patients with MOGAD. ## Methods A retrospective analysis of 289 adult‐ and pediatric‐onset patients with MOGAD followed for at least 2 years in 6 specialized referral centers. “Early relapses” were defined as attacks within the first 12 months from onset, with “very early relapses” defined within 30 to 90 days from onset and “delayed early relapses” defined within 90 to 365 days. “Long‐term relapses” were defined as relapses beyond 12 months. Cox regression modeling and Kaplan–Meier survival analysis were used to estimate the long‐term relapse risk and rate. ## Results Sixty‐seven patients (23.2%) had early relapses with a median number of 1 event. Univariate analysis revealed an elevated risk for long‐term relapses if any “early relapses” were present (hazard ratio [HR] = 2.11, p < 0.001), whether occurring during the first 3 months (HR = 2.70, p < 0.001) or the remaining

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Author

Bo Chen; Enrique Gomez‐Figueroa; Vyanka Redenbaugh; Anna Francis; Chanjira Satukijchai; Yan Wu; Silvia Messina; Mario Sa; Mark Woodhall; Neil P. Robertson; Ming Lim; Evangeline Wassmer; Rachel Kneen; Saif Huda; Camilla Blain; Christopher Halfpenny; Cheryl Hemingway; Eoin O'Sullivan; Jeremy Hobart; Leonora K. Fisniku; Roswell J. Martin; Ruth Dobson; Sarah A. Cooper; Victoria Williams; Patrick Waters; John J. Chen; Sean J. Pittock; Sithara Ramdas; Maria Isabel Leite; Eoin P. Flanagan; Ruth Geraldes; Jacqueline Palace

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)