Can I read Chiral preference of l-tryptophan derived metal-based antitumor agent of late 3d-metal ions (Co(II), Cu(II) and Zn(II)) in comparison to d- and dl-tryptophan analogues: Their in vitro reactivity towards CT DNA, 5′-GMP and 5′-TMP on EtoBox?

Chiral preference of l-tryptophan derived metal-based antitumor agent of late 3d-metal ions (Co(II), Cu(II) and Zn(II)) in comparison to d- and dl-tryptophan analogues: Their in vitro reactivity towards CT DNA, 5′-GMP and 5′-TMP by Farukh Arjmand; Mohd. Muddassir; Rizwan Hasan Khan is a Chemistry article available to read on EtoBox.

What is Chiral preference of l-tryptophan derived metal-based antitumor agent of late 3d-metal ions (Co(II), Cu(II) and Zn(II)) in comparison to d- and dl-tryptophan analogues: Their in vitro reactivity towards CT DNA, 5′-GMP and 5′-TMP about?

## activity a b s t r a c t To evaluate the biological preference of chiral drugs for molecular target DNA, new potential metal-based chemotherapeutic agents 1e3 (aec) of late 3d-transition metals derived from L form, D form, and DLtryptophan, respectively were synthesized and thoroughly characterized. Interaction studies of 1e3 (aec) with CT DNA, 5 0 GMP and 5 0 -TMP have been carried out. The results reveal that the extent of DNA binding of L form of copper 2a was greatest in comparison to rest of complexes via electrostatic interaction. This was further confirmed by nuclease activity of 2a with supercoiled pBR322 DNA and it was observed that cleavage reaction involves various oxygen species and superoxide radicals by oxidative cleavage mechanism. The complex 2a exhibited significant antitumor activity against MCF-7 cell line.

Who reads Chiral preference of l-tryptophan derived metal-based antitumor agent of late 3d-metal ions (Co(II), Cu(II) and Zn(II)) in comparison to d- and dl-tryptophan analogues: Their in vitro reactivity towards CT DNA, 5′-GMP and 5′-TMP?

Author

Farukh Arjmand; Mohd. Muddassir; Rizwan Hasan Khan

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0223-5234)

Published

2010

Language

EN

Field

Chemistry (Physical Sciences)