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Promoter methylation of TGFβ receptor I and mutation of TGFβ receptor II are frequent events in MSI sporadic gastric carcinomas by Mafalda Pinto; Carla Oliveira; Luis Cirnes; José Carlos Machado; Maria Ramires; Ana Nogueira; Fátima Carneiro; Raquel Seruca is a Medicine article available to read on EtoBox.

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## Abstract Transforming growth factor beta (TGFβ) is a potent inhibitor of cell growth, whose action is transduced through interaction between type I (RI) and type II (RII) receptors. Abnormal expression of these receptors has been identified in several human cancers and was found to be associated with resistance to TGFβ. __TGFβ RII__ mutations occur in many types of malignancy. __TGFβ RI__ hypermethylation has been suggested as a cause of abnormal or absent expression of this receptor in cancer. This study has analysed the methylation status of the promoter region of the __TGFβ RI__ gene using a methylation‐sensitive enzyme followed by polymerase chain reaction (PCR), and __TGFβ RII__ mutations (BAT‐RII and a GT~3~) in order to determine the frequency of alteration of the TGFβ receptors in a series of 40 sporadic gastric carcinomas (SGCs), 25 of which showed microsatellite instability (MSI) and 15 of which were microsatellite stable (MSS). Methylation in the promoter region of the __TGFβ RI__ gene was detected in 20 of the 40 (50%) SGCs (64% of the MSI cases and 26.7% of the MSS); 17 of the 40 (42.5%) cases had mutations in the BAT‐RII region of the __TGFβ RII__ gene (68% in the

Who reads Promoter methylation of TGFβ receptor I and mutation of TGFβ receptor II are frequent events in MSI sporadic gastric carcinomas?

Author

Mafalda Pinto; Carla Oliveira; Luis Cirnes; José Carlos Machado; Maria Ramires; Ana Nogueira; Fátima Carneiro; Raquel Seruca

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)

Published

2003

Language

EN

Field

Medicine (Health Sciences)