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Tumor Vascularization in Experimental Melanomas: Correlation Between Unenhanced and Contrast Enhanced Power Doppler Imaging and Histological Grading by Ralf-Juergen Schroeder; Peter Hauff; Thomas Bartels; Kerstin Vogel; Jens Jeschke; Nico Hidajat; Juergen Maeurer is a Medicine article available to read on EtoBox.

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The purpose of this study was to evaluate the reliability of unenhanced and enhanced power Doppler sonography in visualization of intratumoral angioneogenesis. Thirty-seven malignant melanomas, which had been implanted intra-or subcutaneously in 22 mice, were examined. Various B-mode criteria, power Doppler criteria and spectral Doppler parameters were evaluated before and after IV-application of the d-galactose-based contrast agent Levovist. After sonographic examination, all tumors were analyzed histologically with semiquantitative grading of tumoral vascularization. Unenhanced, in 70% of the tumors, no intratumoral vessels were visible using power Doppler, but only in 11% of the intracutaneous and in 0% of the subcutaneous after injection of the contrast agent. The enhanced mode was definitely superior to unenhanced Doppler in showing the intratumoral vascularity. The intratumoral vascular structure could be sufficiently analyzed in 30% of all tumors by unenhanced Doppler, but in 92% enhanced. The mean percentage vessel area increased about 433% after application of Levovist (intracutaneous: 485%, subcutaneous: 280%). Despite the missing direct correlation between the sonographi

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Author

Ralf-Juergen Schroeder; Peter Hauff; Thomas Bartels; Kerstin Vogel; Jens Jeschke; Nico Hidajat; Juergen Maeurer

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0301-5629)

Published

2001

Language

EN

Field

Medicine (Health Sciences)