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Electrochemical Evidence of Increased Dopamine Transmission in Prefkontal Cortex and Nucleus Accumbens Elicited by Ventral Tegmental μ‐Opioid Receptor Activation in Freely Behaving Rats by Miriam Beth Noel; Alain Gratton is a Neuroscience article available to read on EtoBox.
What is Electrochemical Evidence of Increased Dopamine Transmission in Prefkontal Cortex and Nucleus Accumbens Elicited by Ventral Tegmental μ‐Opioid Receptor Activation in Freely Behaving Rats about?
Chronoamperometry was used in combination with monoamine-selective electrodes to monitor, in nucleus accumbens (NAcc) and prefrontal cortex (PFC) of freely behaving rats, changes in dopamine (DA)-like electrochemical signals elicited by unilateral ventral tegmental microinjections of the selective p-opioid receptor agonist D-Ma, N-Me-Phe-Gly-01-Enkephalin (DAMGO; 0.01, 0.1, and 1.0 nmol). The results show that DAMGO dose-dependently increased electrochemical signals both in NAcc and PFC within a few minutes of injection. While DAMGO elicited signal increases of comparable amplitudes in both regions, the increases recorded in PFC were significantly longer lasting than those in NAcc; at the highest dose tested (1.0 nmol), DAMGO produced signal increases that lasted (mean 2 sem) 129 2 7.3 min in PFC and 96 rt 12.5 min in NAcc. Pretreatment with the opioid receptor antagonist, naloxone (2 mgkg, sc), significantly attenuated the peak amplitude and reduced the duration of DAMGO-induced (0.1 nmol) signal increases both in PFC and NAcc. In contrast, pretreatment with apomorphine (50 pg/kg, sc), a DUD2 DA receptor agonist, significantly reduced the duration and the rate of rise of the signa
Who reads Electrochemical Evidence of Increased Dopamine Transmission in Prefkontal Cortex and Nucleus Accumbens Elicited by Ventral Tegmental μ‐Opioid Receptor Activation in Freely Behaving Rats?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Miriam Beth Noel; Alain Gratton
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 1995
- Language
- EN
- Field
- Neuroscience (Life Sciences)