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Bone Mineral Density in Acromegaly: the Effect of Gender, Disease Activity and Gonadal Status by Alfredo Scillitani; Claudia Battista; Iacopo Chiodini; Vincenzo Carnevale; Saverio Fusilli; Enrica Ciccarelli; Massimo Terzolo; Giuseppe Oppizzi; Maura Arosio; Maurizio Gasperi; Giorgio Arnaldi; Annamaria Colao; Roberto Baldelli; Maria Rosaria Ghiggi; Daniela Gaia; Carolina Di Somma; Vincenzo Trischitta; Antonio Liuzzi is a Medicine article available to read on EtoBox.
What is Bone Mineral Density in Acromegaly: the Effect of Gender, Disease Activity and Gonadal Status about?
## Summary **objective** Data on bone mineral density (BMD) in acromegaly are conflicting as most previous studies collectively evaluated eugonadal and hypogonadal patients of both sexes, with or without active disease. We have evaluated BMD in 152 acromegalic patients of both sexes with varying disease activity and gonadal status. **design** Cross‐sectional, retrospective. **patients** We studied 152 acromegalic patients (99 women aged 26–72 years, and 53 men aged 21–75 years), 107 with active and 45 with controlled disease. Eighty‐five patients had normal gonadal status and 67 were hypogonadal. **measurements** In all patients we measured serum GH levels by immunoenzimometric assay, and serum IGF‐I levels by radioimmunoassay. BMD was assessed at spine L2–L4 (LS) and at femoral neck (FN) by dual energy X‐ray absorptiometry; results are expressed as __Z__‐values. **results** We evaluated the effect of GH excess on bone at different sites in relation to gonadal status, disease activity and gender. At LS, in respect to the reference population, BMD (mean ± SE) values were higher in eugonadal patients (active: 0·71 ± 0·29, __P__ < 0·02; controlled: 0·65 ± 0·28, __P__ < 0·05) and lower
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- Author
- Alfredo Scillitani; Claudia Battista; Iacopo Chiodini; Vincenzo Carnevale; Saverio Fusilli; Enrica Ciccarelli; Massimo Terzolo; Giuseppe Oppizzi; Maura Arosio; Maurizio Gasperi; Giorgio Arnaldi; Annamaria Colao; Roberto Baldelli; Maria Rosaria Ghiggi; Daniela Gaia; Carolina Di Somma; Vincenzo Trischitta; Antonio Liuzzi
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)