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The Neurotrophic Activities of Brain‐derived Neurotrophic Factor Are Potentiated by Binding with Apigenin, a Common Flavone in Vegetables, in Stimulating the Receptor Signaling by Alex Xiong Gao; Tracy Chen‐Xi Xia; Lish Sheng‐Ying Lin; Tina Ting‐Xia Dong; Karl Wah‐Keung Tsim is a Neuroscience article available to read on EtoBox.
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## Abstract ## Aims We aimed to identify the neurotrophic activities of apigenin (4′,5,7‐trihydroxyflavone) via its coordination with brain‐derived neurotrophic factor (BNDF) and an elevated signaling of tyrosine kinase receptor B (Trk B receptor). ## Methods The direct binding of apigenin to BDNF was validated by ultrafiltration and biacore assay. Neurogenesis, triggered by apigenin and/or BDNF, was determined in cultured SH‐SY5Y cells and rat cortical neurons. The amyloid‐beta (Aβ)~25‐35~‐induced cellular stress was revealed by propidium iodide staining, mitochondrial membrane potential, bioenergetic analysis, and formation of reactive oxygen species levels. Activation of Trk B signaling was tested by western blotting. ## Results Apigenin and BDNF synergistically maintained the cell viability and promoted neurite outgrowth of cultured neurons. In addition, the BDNF‐induced neurogenesis of cultured neurons was markedly potentiated by applied apigenin, including the induced expressions of neurofilaments, PSD‐95 and synaptotagmin. Moreover, the synergy of apigenin and BDNF alleviated the (Aβ)~25‐35~‐induced cytotoxicity and mitochondrial dysfunction. The synergy could be accounted b
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- Author
- Alex Xiong Gao; Tracy Chen‐Xi Xia; Lish Sheng‐Ying Lin; Tina Ting‐Xia Dong; Karl Wah‐Keung Tsim
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Neuroscience (Life Sciences)