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Hesperidin and eugenol attenuate cadmium-induced nephrotoxicity via regulation of oxidative stress, Bax/Bcl2 and cleaved caspase 3 expression by Rasha Hussein; Marwa Khalaf; Wafaa Mohamed is a Medicine article available to read on EtoBox.

What is Hesperidin and eugenol attenuate cadmium-induced nephrotoxicity via regulation of oxidative stress, Bax/Bcl2 and cleaved caspase 3 expression about?

Objectives: Cadmium (Cd) is a heavy metal that induces nephrotoxicity through stimulating the oxidative stress in kidney cells. In this study, we investigated the protective effects of hesperidin and eugenol on Cd-induced nephrotoxicity and their impact on modulating oxidative stress, Bax/Bcl2 ratio and cleaved caspase 3 level. Methods: Male Wistar rats were divided into: Normal group; Cd-treated group; hesperidin & Cd-treated group and eugenol & Cd-treated group. Rats received CdCl 2 (5 mg/ kg body weight/daily) via oral gavage for four weeks to induce kidney toxicity. Results: The results showed that, both hesperidin & Cd and eugenol & Cd-treated groups exhibited lower serum creatinine and urea levels as well as better kidney tissue integrity compared to the Cd-treated group. Moreover, they could preserve the cellular antioxidants to normal levels as was seen in a significantly lower malondialdehyde content, but significantly higher catalase and superoxide dismutase activities compared to the Cd-treated group. Furthermore, both groups significantly decreased the Cd-induced elevation in Bax/Bcl2 ratio and cleaved caspase 3 level. Conclusion: Administration of hesperidin or eugenol

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Author

Rasha Hussein; Marwa Khalaf; Wafaa Mohamed

Publisher

Walter de Gruyter GmbH

Published

2020

Language

EN

Field

Medicine (Health Sciences)