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Solid-phase synthesis of α-hydroxy phosphonates and hydroxystatine amides. Transition-state isosteres derived from resin-bound amino acid aldehydes by Roland E Dolle; Timothy F Herpin; Yvonne Class Shimshock is a Chemistry article available to read on EtoBox.

What is Solid-phase synthesis of α-hydroxy phosphonates and hydroxystatine amides. Transition-state isosteres derived from resin-bound amino acid aldehydes about?

Resin-bound N-acylated amino acid aldehydes iv were converted in a single step to a-hydroxy phosphonates vii (Pudovik reaction) and in six-steps to hydroxystatine amides viii, demonstrating the utility of intermediates iv for constructing multiple aspartic acid transition-state isosteres.

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Author

Roland E Dolle; Timothy F Herpin; Yvonne Class Shimshock

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0040-4039)

Published

2001

Language

EN

Field

Chemistry (Physical Sciences)