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15P The genomic landscape of pleomorphic lung cancer using whole exome sequencing by L. Roma; C. Ercan; F. Conticelli; S. Piscuoglio; C. Ky Ng; L. Bubendorf is a Medicine article available to read on EtoBox.

What is 15P The genomic landscape of pleomorphic lung cancer using whole exome sequencing about?

others. Moreover, preoperative patients' blood was analyzed for circulating tumor cells (CTCs) using the Parsortix platform and gene expression analysis. Results: We surgically implanted more than 50 primary specimens from patients with early stage operable NSCLC. Over 50% of those grafted successfully. Our results indicate that the ability of primary tumors to successfully graft correlates significantly with tumor stage and grade, primary tumor size, and the detection of CTCs. Moreover, we observed that squamous cell carcinomas are more likely to graft than adenocarcinomas. Other than mutations associated tumor type (squamous vs. adeno), we did not observe any combination of mutations favors or disfavors grafting ability. The comparison between the genetic profile of the primary tumor and the PDX revealed differences in some cases. Detailed results will be presented. Conclusions: Primary early stage tumor samples from NSCLC patients graft efficiently in immunocompromised mice while the grafting efficiency is affected by the tumoral clinic-pathological characteristics. Legal entity responsible for the study: The authors. Funding: AstraZeneca.

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Author

L. Roma; C. Ercan; F. Conticelli; S. Piscuoglio; C. Ky Ng; L. Bubendorf

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)