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A Prospective Cardiac Screening Study in Asymptomatic Long-term Survivors of Hodgkin's Lymphoma Treated with Mediastinal Radiation Therapy by Chen, M.H.; Ng, A.K.; Chu, T.F.; Zhou, J.; Gauvreau, K.; Mauch, P.M. is a Medicine article available to read on EtoBox.

What is A Prospective Cardiac Screening Study in Asymptomatic Long-term Survivors of Hodgkin's Lymphoma Treated with Mediastinal Radiation Therapy about?

Materials/Methods: For 187 HL survivors who developed NSCLC (HL-LC group) and 178,431 patients with a first or only NSCLC (LC-1 group), actuarial OS were compared, accounting for gender (34% of HL-LC group are female), race, sociodemographic status, radiation for HL, calendar year of NSCLC diagnosis, age at NSCLC diagnosis, NSCLC stage and NSCLC histology. All patients were derived from the population-based Surveillance, Epidemiology, and End Results program. Results: The NSCLC stage distribution of the HL-LC and LC-1 groups are similar: ?20% localized, ?30% regional and ?50% distant. For the HL-LC group, with more advanced NSCLC stage, there was a significant trend towards younger age at the time of HL diagnosis (median age 58, 51 and 42 years for localized, regional and distant NSCLC respectively, p \ 0.0001), younger age at the time of NSCLC diagnosis (median age 64, 60 and 58 years, p = 0.014), and longer latency between HL and NSCLC (median 6.9, 10.8 and 14.4 years, p = 0.0003). The HL-LC group was significantly younger than the LC-1 group for each NSCLC stage. For localized and regional NSCLC, the HL-LC group had a greater percentage of patients with squamous cell histology.

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Author

Chen, M.H.; Ng, A.K.; Chu, T.F.; Zhou, J.; Gauvreau, K.; Mauch, P.M.

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2010

Language

EN

Field

Medicine (Health Sciences)