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Surfactant Therapy in Late Preterm and Term Neonates with Respiratory Distress Syndrome: a Systematic Review and Meta-analysis by Viraraghavan Vadakkencherry Ramaswamy; Thangaraj Abiramalatha; Tapas Bandyopadhyay; Elaine Boyle; Charles Christoph Roehr is a Medicine article available to read on EtoBox.

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## Background There are no evidence-based recommendations for surfactant use in late preterm (LPT) and term infants with respiratory distress syndrome (RDS). ## Objective To investigate the safety and efficacy of surfactant in LPT and term infants with RDS. ## Methods Systematic review, meta-analysis and evidence grading. ## Interventions Surfactant therapy versus standard of care. ## Main outcome measures Mortality and requirement for invasive mechanical ventilation (IMV). ## Results Of the 7970 titles and abstracts screened, 17 studies (16 observational studies and 1 randomised controlled trial (RCT)) were included. Of the LPT and term neonates with RDS, 46% (95% CI 40% to 51%) were treated with surfactant. We found moderate certainty of evidence (CoE) from observational studies evaluating infants supported with non-invasive respiratory support (NRS) or IMV that surfactant use may be associated with a decreased risk of mortality (OR 0.45, 95% CI 0.32 to 0.64). Very low CoE from observational trials in which surfactant was administered at FiO~2~ >0.30–0.40 to infants on Continuous Positive Airway Pressure (CPAP) indicated that surfactant did not decrease the risk of IMV (OR 1.20,

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Author

Viraraghavan Vadakkencherry Ramaswamy; Thangaraj Abiramalatha; Tapas Bandyopadhyay; Elaine Boyle; Charles Christoph Roehr

Publisher

BMJ

Published

2021

Language

EN

Field

Medicine (Health Sciences)