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Can I read Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers on EtoBox?
Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers by Lizbeth DeSelm; Bayard Huck; Ruoxi Lan; Constantin Neagu; Justin Potnick; Yufang Xiao; Xiaoling Chen; Reinaldo Jones; Thomas E. Richardson; Brian H. Heasley; Thomas Haxell; Joseph Moore; Hui Tian; Katrin Georgi; Felix Rohdich; Amanda Sutton; Theresa Johnson; Igor Mochalkin; Jennifer Jackson; Jing Lin; Lindsey Crowley; Andreas Machl; Anderson Clark; Erik Wilker; Brian Sherer; Andreas Goutopoulos is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers about?
Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase library, 4-benzylamino-quinazoline-8-carboxylic acid amide stood out, with sub-micromolar p70S6k biochemical activity, as the starting point for a structurally enabled p70S6K/Akt dual inhibitor program that led to the discovery of M2698, a dual p70S6k/Akt inhibitor. M2698 is kinase selective, possesses favorable physical, chemical, and DMPK profiles, is orally available and well tolerated, and displayed tumor control in multiple studies of PAM pathway-driven tumors.
Who reads Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lizbeth DeSelm; Bayard Huck; Ruoxi Lan; Constantin Neagu; Justin Potnick; Yufang Xiao; Xiaoling Chen; Reinaldo Jones; Thomas E. Richardson; Brian H. Heasley; Thomas Haxell; Joseph Moore; Hui Tian; Katrin Georgi; Felix Rohdich; Amanda Sutton; Theresa Johnson; Igor Mochalkin; Jennifer Jackson; Jing Lin; Lindsey Crowley; Andreas Machl; Anderson Clark; Erik Wilker; Brian Sherer; Andreas Goutopoulos
- Publisher
- American Chemical Society (ACS)
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)