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Role of Serum Androgens and Sex Hormone Binding Globulin Capacity in the Evaluation of Hirsutism in Women by J.L. Andreyko; B.R. Bhavnani; J.A. Nisker; W.H.C. Walker; C.A. Woolever is a Medicine article available to read on EtoBox.

What is Role of Serum Androgens and Sex Hormone Binding Globulin Capacity in the Evaluation of Hirsutism in Women about?

Serum samples from 23 hirsute women and 23 non-hirsute women matched for age and deviation from ideal weight were analyzed for total testosterone (T), percent free testosterone (% FT) and sex hormone binding globulin capacity (SHBG). The % FT was assayed by 2 methods, using diluted serum in equilibrium dialysis (EQD) and using undiluted serum in centrifugal ultra-filtration (UF). SHBG was measured by a DEAE cellulose filter assay and T by radioimmunoassay. The two methods for determining % FT correlated well. There was considerable overlap between the hirsute and control groups for all of the measured parameters. The discrimination between the 2 groups provided by the indirect estimate of free testosterone obtained from the ratio of T to SHBG was at least as good as that provided by the free testosterone derived from ultrafiltration or dialysis.

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Author

J.L. Andreyko; B.R. Bhavnani; J.A. Nisker; W.H.C. Walker; C.A. Woolever

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0009-9120)

Published

1986

Language

EN

Field

Medicine (Health Sciences)