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Synthesis and Evaluation of Antitumoral Activity of Ester and Amide Derivatives of 2-Arylamino-6-trifluoromethyl-3-pyridinecarboxylic Acids by Valentina Onnis; Maria T. Cocco; Valentina Lilliu; Cenzo Congiu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The synthesis and antitumoral activity of ester and amide derivatives of 2-arylamino-6-trifluoromethyl-3-pyridinecarboxylic acids 8-58 is described. Trifluoromethylpyridine derivatives 8-58 were evaluated for their anticancer activity toward human tumoral cell lines by the National Cancer Institute (NCI). Most of them possess encouraging anticancer activity, having GI 50 values in the low micromolar to nanomolar concentration range. The 3,4,5-trimethoxyphenylamide 44 was the most active, and it is now under review by NCI Biological Evaluation Committee for possible further studies.

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Author

Valentina Onnis; Maria T. Cocco; Valentina Lilliu; Cenzo Congiu

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2008

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)