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What is Nuclear Receptors in Metabolic Disease about?
Nuclear receptors (NRs) are a family of ligand-activated transcription factors that regulate metabolism. NRs integrate metabolic homeostasis by controlling gene expression in response to hormones, vitamins, and other signals. Genetic studies support the important role of NRs in metabolic diseases like diabetes, dyslipidemia, and obesity. In the absence of ligand, NRs repress transcription by associating with corepressors. Ligand binding induces a conformational change, causing dissociation from corepressors
- Author
- Muntathar Ali
- Language
- EN