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Clinical evaluation of antimicrobial peptide [99mTc/Tricine/HYNIC0]ubiquicidin 29–41 as a human-specific infection imaging agent by Mostafa Gandomkar; Reza Najafi; Mohammad Shafiei; Mohammad Mazidi; Mostafa Goudarzi; Seyed Hassan Mirfallah; Farhad Ebrahimi; Hamid Reza Heydarpor; Noroz Abdie is a Medicine article available to read on EtoBox.

What is Clinical evaluation of antimicrobial peptide [99mTc/Tricine/HYNIC0]ubiquicidin 29–41 as a human-specific infection imaging agent about?

## Introduction: Ubiquicidin (ubi) 29-41 is a cationic synthetic antimicrobial peptide fragment that binds preferentially with the anionic microbial cell membrane at the site of infection. this study was conducted to evaluate the potentiality of [(99m)tc/tricine/hynic(0)]ubi 29-41 prepared from lyophilized kits as an infection imaging agent in humans. ## Methods: Seven patients (5 males and 2 females; mean age=55 years; age range=35-75 years) with suspected bone or soft-tissue infections participated in this study. [(99m)tc/tricine/hynic]ubi 29-41, corresponding to activity in the range 555-740 mbq added to 40 mug of peptide obtained from instant freeze-dried kit formulations with radiochemical purities >95%, was injected intravenously. a 45-min dynamic study was followed by spot views of the suspected region of infection (target) and a corresponding normal area (nontarget). whole-body anterior and posterior images were also acquired at 30, 60 and 120 min after injection. true- or false-positive or true- or false-negative images were interpreted upon bacterial culture, radiography, clinical tests and bone scanning. ## Results: The biodistribution of [(99m)tc/tricine/hynic]ubi 29-41

Who reads Clinical evaluation of antimicrobial peptide [99mTc/Tricine/HYNIC0]ubiquicidin 29–41 as a human-specific infection imaging agent?

Author

Mostafa Gandomkar; Reza Najafi; Mohammad Shafiei; Mohammad Mazidi; Mostafa Goudarzi; Seyed Hassan Mirfallah; Farhad Ebrahimi; Hamid Reza Heydarpor; Noroz Abdie

Publisher

Elsevier BV

Published

2009

Language

EN

Field

Medicine (Health Sciences)