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Can I read Diverse effects of different Akkermansia muciniphila genotypes on Brown adipose tissue inflammation and whitening in a high-fat-diet murine model on EtoBox?
Diverse effects of different Akkermansia muciniphila genotypes on Brown adipose tissue inflammation and whitening in a high-fat-diet murine model by Lulu Deng; Zihao Ou; Dongquan Huang; Chong Li; Zhi Lu; Wanting Liu; Feifan Wu; Caihong Nong; Jie Gao; Yongzheng Peng is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Diverse effects of different Akkermansia muciniphila genotypes on Brown adipose tissue inflammation and whitening in a high-fat-diet murine model about?
## Background: The purpose of this study was to investigate the differences in the metabolic protective effects of akkermansia muciniphila (a.muciniphila) genotypes on high-fat diet mice and explore possible mechanisms. ## Methods: Male c57bl/6 mice were randomly divided into 6 groups, including high-fat diet (hfd)+ a. muciniphila i/ii/pbs group, normal control diet (ncd)+ a. muciniphila i/ii/pbs group, respectively. dietary intervention and a. muciniphila gavage were performed simultaneously. blood glucose and lipid metabolism, brown adipose morphology and activities, and intestinal barrier function were examined after the mice were sacrificed. ## Results: A.muciniphila gavage improved the impaired glucose tolerance, hyperlipidemia and liver steatosis in hfd mice, and that a. muciniphila ii (amuc\_gp25) was not as effective as a. muciniphila i (amuc\_gp01). this phenomenon might be because amuc\_gp01 intervention significantly inhibited brown adipose tissue whitening and inflammation induced by hfd, by repairing the intestinal barrier and relieving endotoxemia. amuc\_gp25 did not display the same results as amuc\_gp01 in hfd mice but had stronger effects in the ncd mice. ## Conclu
Who reads Diverse effects of different Akkermansia muciniphila genotypes on Brown adipose tissue inflammation and whitening in a high-fat-diet murine model?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lulu Deng; Zihao Ou; Dongquan Huang; Chong Li; Zhi Lu; Wanting Liu; Feifan Wu; Caihong Nong; Jie Gao; Yongzheng Peng
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)