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American J Hematol - 2023 - Falini - NPM1 Mutated Acute Myeloid Leukemia New Pathogenetic and Therapeutic Insights and by Emiliano Bertone is a document available to read on EtoBox.

What is American J Hematol - 2023 - Falini - NPM1 Mutated Acute Myeloid Leukemia New Pathogenetic and Therapeutic Insights and about?

The document reviews NPM1-mutated acute myeloid leukemia (AML), highlighting the prevalence and specific mutations associated with this type of leukemia. It discusses the mechanisms of leukemogenesis, the significance of cytoplasmic NPM1c, and the implications for diagnosis and therapy, including the potential of targeted therapies like CAR T cells and inhibitors. Additionally, it addresses open questions regarding therapy-related NPM1-mutated AML and the challenges in classification and diagnosis.

Author

Emiliano Bertone

Language

EN