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Beta-blockers Reduce the Release and Synthesis of Endothelin-1 in Human Endothelial Cells by Garlichs; Zhang; Mügge; Daniel is a Medicine article available to read on EtoBox.

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## Background: Endothelins play an important role in cardiovascular diseases, and clinical trials have shown a reduction in endothelin levels after long-term treatment of chronic heart failure with beta-adrenergic antagonists. it is not known, however, whether this effect is caused by haemodynamic changes associated with the use of beta-adrenergic antagonists or by direct interaction of beta-blockers with human endothelial cells. the aim of this study was to determine whether beta-adrenergic antagonists have an influence on endothelin-1 (et-1) synthesis and release in human endothelial cells. ## Methods: Pretreatment of cultured endothelial cells from human umbilical veins (huvecs) with different concentrations of the non-selective beta-blocker propranolol, the beta 1-blocker metoprolol and the beta 1-blocker and beta 2-agonist celiprolol (all 10(-7)-10(-4) mol l-1) was found to reduce et-1 production. this et-1-reducing effect was even more pronounced in thrombin-stimulated cells (10(-5) mol l-1 of propranolol, metoprolol and celiprolol: 19% +/- 5.8%, 25% +/- 4% and 37% +/- 5.2% respectively). ## Results: Quantitative reverse transcriptase polymerase chain reaction and northern bl

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Author

Garlichs; Zhang; Mügge; Daniel

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0014-2972)

Published

1999

Language

EN

Field

Medicine (Health Sciences)