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Vascular injury markers associated with cognitive impairment in people with HIV on suppressive antiretroviral therapy by Debjani Guha; Vikas Misra; Jun Yin; Miki Horiguchi; Hajime Uno; Dana Gabuzda is a scholarly article available to read on EtoBox.

What is Vascular injury markers associated with cognitive impairment in people with HIV on suppressive antiretroviral therapy about?

## Objective: Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) remain prevalent despite viral suppression on antiretroviral therapy (ART). Vascular disease contributes to HAND, but peripheral markers that distinguish vascular cognitive impairment (VCI) from HIV-related etiologies remain unclear. ## Design: Cross-sectional study of vascular injury, inflammation, and central nervous system (CNS) injury markers in relation to HAND. ## Methods: Vascular injury (VCAM-1, ICAM-1, CRP), inflammation (IFN-γ, IL-1β, IL-6, IL-8, IL-15, IP-10, MCP-1, VEGF-A), and CNS injury (NFL, total Tau, GFAP, YKL-40) markers were measured in plasma and CSF from 248 individuals (143 HIV+ on suppressive ART and 105 HIV− controls). ## Results: Median age was 53 years, median CD4 count, and duration of HIV infection were 505 cells/μl and 16 years, respectively. Vascular injury, inflammation, and CNS injury markers were increased in HIV+ compared with HIV− individuals (p<0.05). HAND was associated with increased plasma VCAM-1, ICAM-1, and YKL-40 (p<0.01) and vascular disease (p=0.004). In contrast, inflammation markers had no significant association with HAND. Vascular injury marker

Author

Debjani Guha; Vikas Misra; Jun Yin; Miki Horiguchi; Hajime Uno; Dana Gabuzda

Publisher

Cold Spring Harbor Laboratory

Published

2023

Language

EN