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A pilot study of new promising non-coding RNA diagnostic biomarkers for early-stage colorectal cancers by Hanshao Liu; Deji Ye; Aijun Chen; Dan Tan; Wenpeng Zhang; Wenxia Jiang; Mingliang Wang; Xiaoren Zhang is a Medicine article available to read on EtoBox.

What is A pilot study of new promising non-coding RNA diagnostic biomarkers for early-stage colorectal cancers about?

## Abstract ## Background Diagnostic biomarkers for the detection of colorectal cancers (CRCs) are lacking. Recent studies have demonstrated that circulating long non-coding RNAs have the potential to serve as biomarkers for the detection of cancers. We analyzed the significance of lncRNAs 91H, PVT-1 and MEG3 in the detection of CRC. ## Methods We examined the expression levels of 13 candidate lncRNAs in the plasma of 18 CRC patients and 20 non-cancerous controls. Then, we validated our findings by determining the expression levels of six promising lncRNAs in CRC tissues and normal colorectal tissues. Finally, we evaluated the clinical relevance of lncRNAs 91H, PVT-1 and MEG3 in the plasma of 58 CRC patients and 56 non-cancerous controls. ## Results Our data revealed that the expression levels of lncRNAs 91H, PVT-1 and MEG3 were significantly higher in plasma samples from CRC patients than in those from non-cancerous controls. The combination of 91H, PVT-1 and MEG3 could discriminate CRC patients from non-cancerous controls with an area under the receiver-operating curve (AUC) of 0.877 at a cut-off value of 0.3816, with a sensitivity of 82.76% and 78.57% specificity. More important

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Author

Hanshao Liu; Deji Ye; Aijun Chen; Dan Tan; Wenpeng Zhang; Wenxia Jiang; Mingliang Wang; Xiaoren Zhang

Publisher

Walter de Gruyter GmbH

Published

2019

Language

EN

Field

Medicine (Health Sciences)