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Design of Bicyclic Peptide Tandems Mimicking The Homodimeric Gdf15 Protein To Inhibit Gdf15 Gfral Ret Complex Cell by applicationaig5 is a document available to read on EtoBox.
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This article discusses the design and development of bicyclic peptide tandems that mimic the homodimeric GDF15 protein to inhibit the GDF15−GFRaL−RET signaling complex, which is implicated in various diseases. The study utilized structure-guided design and phage display to create high-affinity peptide inhibitors that effectively disrupt the protein-protein interaction, demonstrating improved pharmacokinetic properties compared to monomeric counterparts. This work represents a novel approach to targeting the
- Author
- applicationaig5
- Language
- EN