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Search for MHC-associated genes in human: five new genes centromeric to HLA-DP with yet unknown functions by Mahmoud Janatipour; Yuri Naumov; Asako Ando; Kazuhito Sugimura; Naoaki Okamoto; Kimiyoshi Tsuji; Kuniya Abe; Hidetoshi Inoko is a Immunology and Microbiology article available to read on EtoBox.
What is Search for MHC-associated genes in human: five new genes centromeric to HLA-DP with yet unknown functions about?
Taking advantage of five mouse genomic or cDNA probes [KE5(probe 14), KE4 (probe 11), KE3 (probe 7), KE2 (probe 5), and SET] mapped on the H-2Kregion in mouse, we have identified and localized homologues of these five genes in the human major histocompatibility complex region (HKE5, HKE4, HKE3, HKE2, and HSET, respectively). Cosmid cloning and pulsed field gel electrophoresis analyses indicated that a human homologous gene, HKE5, is located 10 kilobases (kb) centromeric of the c¢2(XI) collagen (COLllA2) gene followed by HKE4. HKE3, closely linked to HKE2, is located 170 kb centromeric of HKE4. Furthermore, HSET is located 50 kb centromeric of HKE2. This gene organization outside the DP subregion is completely identical to that of the mouse H-2Kregion centromeric of I-Pb 3, a mouse homologue of the DPB gene, except the lack of genes corresponding to the H-2K and -K2 genes in human.
Who reads Search for MHC-associated genes in human: five new genes centromeric to HLA-DP with yet unknown functions?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Mahmoud Janatipour; Yuri Naumov; Asako Ando; Kazuhito Sugimura; Naoaki Okamoto; Kimiyoshi Tsuji; Kuniya Abe; Hidetoshi Inoko
- Publisher
- Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0093-7711)
- Published
- 1992
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)