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Epstein‐Barr virus‐associated gastric carcinoma among patients with pernicious anemia by Trine Boysen; Jeppe Friborg; Katrine Stribolt; Stephen Hamilton‐Dutoit; Sanne Goertz; Jan Wohlfahrt; Mads Melbye is a Medicine article available to read on EtoBox.

What is Epstein‐Barr virus‐associated gastric carcinoma among patients with pernicious anemia about?

## Abstract Approximately 9% of gastric carcinomas worldwide are associated with Epstein‐Barr virus (EBV), making it the most frequent EBV‐associated malignancy. Pernicious anemia, a condition with chronic gastritis and achlorhydria, is strongly associated with gastric carcinoma. Both chronic inflammation and the lack of stomach acid may influence the likelihood of EBV infection of the neoplastic gastric epithelium, but the prevalence of EBV‐associated gastric carcinoma among patients with pernicious anemia is unknown. Therefore, we conducted a Danish nationwide case–control study comparing gastric carcinoma patients with pernicious anemia (PA‐GC) with those without pernicious anemia (nonPA‐GC), frequency matched 1:2. Tumor tissues were reclassified by expert histopathologists blinded to pernicious anemia and EBV status. In total, 186 samples (55 PA‐GC and 131 nonPA‐GC) were identified. EBV‐associated gastric carcinoma (EBV‐GC) was more common among PA‐GC compared with nonPA‐GC, adjusted odds ratio (OR) = 2.53 (CI: 0.88; 7.14), __p__ = 0.08, with further adjustment for lymphocytic infiltrate OR = 2.94 (0.99–8.67), __p__ = 0.05. Gastric carcinomas with signet‐ring cell morphology we

Who reads Epstein‐Barr virus‐associated gastric carcinoma among patients with pernicious anemia?

Author

Trine Boysen; Jeppe Friborg; Katrine Stribolt; Stephen Hamilton‐Dutoit; Sanne Goertz; Jan Wohlfahrt; Mads Melbye

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2011

Language

EN

Field

Medicine (Health Sciences)