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Osteoclast and Osteoblast Response to Strontium-doped Struvite Coatings on Titanium for Improved Bone Integration by Claus Moseke; Katharina Wimmer; Markus Meininger; Julia Zerweck; Cornelia Wolf-Brandstetter; Uwe Gbureck; Andrea Ewald is a Medicine article available to read on EtoBox.

What is Osteoclast and Osteoblast Response to Strontium-doped Struvite Coatings on Titanium for Improved Bone Integration about?

## Abstract To develop implants with improved bone ingrowth, titanium substrates were coated with homogeneous and dense struvite (MgNH~4~PO~4~·6H~2~O) layers by means of electrochemically assisted deposition. Strontium nitrate was added to the coating electrolyte in various concentrations, in order to fabricate Sr-doped struvite coatings with Sr loading ranging from 10.6 to 115 μg/cm^2^. It was expected and observed that osteoclast activity surrounding the implant was inhibited. The cytocompatibility of the coatings and the effect of Sr-ions in different concentrations on osteoclast formation were analyzed in vitro. Osteoclast differentiation was elucidated on morphological, biochemical as well as on gene expression level. It could be shown that moderate concentrations of Sr^2+^ had an inhibitory effect on osteoclast formation, while the growth of osteoblastic cells was not negatively influenced compared to pure struvite surfaces. In summary, the electrochemically deposited Sr-doped struvite coatings are a promising approach to improve bone implant ingrowth.

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Author

Claus Moseke; Katharina Wimmer; Markus Meininger; Julia Zerweck; Cornelia Wolf-Brandstetter; Uwe Gbureck; Andrea Ewald

Publisher

Walter de Gruyter GmbH

Published

2020

Language

EN

Field

Medicine (Health Sciences)