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Dectin-1 is required for human dendritic cells to initiate immune response to Candida albicans through Syk activation by Franck Skrzypek; Elio Cenci; Donatella Pietrella; Anna Rachini; Francesco Bistoni; Anna Vecchiarelli is a Medicine article available to read on EtoBox.

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Dectin-1 is a pattern recognition receptor found on monocytes and dendritic cells (DC) able to recognize b-1,3 and b-1,6 glucans. It is thought to act via the spleen tyrosine kinase (Syk) to initiate immune response against infectious agents such as Candida albicans, one of the leading causes of invasive fungal disease in immunocompromised individuals. This study addresses the importance of this receptor in the context of human DC response to C. albicans. Upon blockage of Dectin-1, immature DC are less able than untreated cells to bind, phagocytose, and kill C. albicans via oxidative burst. In fact, a consistent decrease in superoxide anion, but not nitric oxide production, was manifested when the Syk pathway was inhibited. C. albicans-induced cytokine production via Dectin-1 recognition is mediated by the Syk activation pathway. Indeed, specific Syk inhibition significantly suppressed the production of IL-12, IL-6, and TNF-a. Finally, we observed that Dectin-1 engagement was also involved in DC maturation and subsequent lymphocyte activation. Collectively, these findings identify Dectin-1 as a key receptor influencing critical biological functions of DC in response to C. albicans

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Author

Franck Skrzypek; Elio Cenci; Donatella Pietrella; Anna Rachini; Francesco Bistoni; Anna Vecchiarelli

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1286-4579)

Published

2009

Language

EN

Field

Medicine (Life Sciences)