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Can I read Efficacy of Nilotinib in a CML Patient Expressing the Three-way Complex Variant Translocation t(2;9;22) on EtoBox?
Efficacy of Nilotinib in a CML Patient Expressing the Three-way Complex Variant Translocation t(2;9;22) by ELENA TIRRÒ; MICHELE MASSIMINO; STEFANIA STELLA; VALENTINA ZAMMIT; MARIA LETIZIA CONSOLI; MARIA STELLA PENNISI; SILVIA RITA VITALE; CHIARA ROMANO; MARIA CRISTINA PIROSA; ENRICA MARTINO; SANDRA DI GREGORIO; ADRIANA PUMA; FRANSCESCO DI RAIMONDO; LIVIA MANZELLA; FABIO STAGNO is a Medicine article available to read on EtoBox.
What is Efficacy of Nilotinib in a CML Patient Expressing the Three-way Complex Variant Translocation t(2;9;22) about?
## Background/aim: Chronic myelogenous leukemia (cml) is characterized by the presence of the philadelphia chromosome, resulting from the reciprocal translocation involving chromosomes 9 and 22. about 5-10% of newly diagnosed patients in chronic-phase (cp) cml show complex additional chromosomal aberrations (aca), that may involve one or more chromosomes in addition to 9 and 22. data concerning the prognostic significance of aca in cp-cml subjects at diagnosis are controversial. furthermore, there is no evidence showing that selection of imatinib (im) or second-generation tyrosine kinase inhibitors (2g-tki) would be of benefit for these patients. ## Case report: We report the three-way complex variant translocation t(2;9;22) in a cp-cml patient. conventional cytogenetic analysis was employed to identify the aca. multiplex reverse transcription-pcr was used to identify the bcr-abl1 transcript and its levels were measured using quantitative real-time-pcr. this rare aca t(2;9;22) in our young patient displayed primary resistance to im, but was responsive to second-line treatment with nilotinib. ## Conclusion: Cp-cml patients exhibiting this rare aberration at diagnosis may benefit fro
Who reads Efficacy of Nilotinib in a CML Patient Expressing the Three-way Complex Variant Translocation t(2;9;22)?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- ELENA TIRRÒ; MICHELE MASSIMINO; STEFANIA STELLA; VALENTINA ZAMMIT; MARIA LETIZIA CONSOLI; MARIA STELLA PENNISI; SILVIA RITA VITALE; CHIARA ROMANO; MARIA CRISTINA PIROSA; ENRICA MARTINO; SANDRA DI GREGORIO; ADRIANA PUMA; FRANSCESCO DI RAIMONDO; LIVIA MANZELLA; FABIO STAGNO
- Publisher
- Anticancer Research USA Inc.
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)