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Frequency of Atypical Mutations in the Spike Glycoprotein in SARS-CoV-2 Circulating from July 2020 to July 2022 in Central Italy: A Refined Analysis by Next Generation Sequencing by Maria Concetta Bellocchi; Rossana Scutari; Luca Carioti; Marco Iannetta; Greta Marchegiani; Lorenzo Piermatteo; Luigi Coppola; Simona Tedde; Leonardo Duca; Vincenzo Malagnino; Lorenzo Ansaldo; Neva Braccialarghe; Stefano D′Anna; Maria Mercedes Santoro; Andrea Di Lorenzo; Romina Salpini; Elisabetta Teti; Valentina Svicher; Massimo Andreoni; Loredana Sarmati; Francesca Ceccherini-Silberstein; on behalf of the PTV-UTV-ID-COVID Group is a Medicine article available to read on EtoBox.

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In this study, we provided a retrospective overview in order to better define SARS-CoV-2 variants circulating in Italy during the first two years of the pandemic, by characterizing the spike mutational profiles and their association with viral load (expressed as ct values), N-glycosylation pattern, hospitalization and vaccination. Next-generation sequencing (NGS) data were obtained from 607 individuals (among them, 298 vaccinated and/or 199 hospitalized). Different rates of hospitalization were observed over time and among variants of concern (VOCs), both in the overall population and in vaccinated individuals (Alpha: 40.7% and 31.3%, Beta: 0%, Gamma: 36.5% and 44.4%, Delta: 37.8% and 40.2% and Omicron: 11.2% and 7.1%, respectively, both __p__-values 90%), with a distribution differing among the strains (22.9% in Alpha, 14.3% in Beta, 41.8% in Gamma, 46.5% in Delta and 15.4% in Omicron, __p__-value < 0.001). Overall, significantly less atypical variability was observed in vaccinated individuals than unvaccinated individuals; nevertheless, vaccinated people who needed hospitalization showed an increase in atypical variability compared to vaccinated people that did not need hospita

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Author

Maria Concetta Bellocchi; Rossana Scutari; Luca Carioti; Marco Iannetta; Greta Marchegiani; Lorenzo Piermatteo; Luigi Coppola; Simona Tedde; Leonardo Duca; Vincenzo Malagnino; Lorenzo Ansaldo; Neva Braccialarghe; Stefano D′Anna; Maria Mercedes Santoro; Andrea Di Lorenzo; Romina Salpini; Elisabetta Teti; Valentina Svicher; Massimo Andreoni; Loredana Sarmati; Francesca Ceccherini-Silberstein; on behalf of the PTV-UTV-ID-COVID Group

Publisher

MDPI AG

Published

2023

Language

EN

Field

Medicine (Health Sciences)