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Transtympanic Injections of N-acetylcysteine for the Prevention of Cisplatin-induced Ototoxicity: A Feasible Method With Promising Efficacy by Maria G. Riga; Leonidas Chelis; Stylianos Kakolyris; Stergios Papadopoulos; Sofia Stathakidou; Eleni Chamalidou; Nikolaos Xenidis; Kyriakos Amarantidis; Prokopios Dimopoulos; Vasilios Danielides is a Medicine article available to read on EtoBox.
What is Transtympanic Injections of N-acetylcysteine for the Prevention of Cisplatin-induced Ototoxicity: A Feasible Method With Promising Efficacy about?
## Objectives: Ototoxicity is a common and irreversible adverse effect of cisplatin treatment with great impact on the patients' quality of life. n-acetylcysteine is a low-molecular-weight agent which has shown substantial otoprotective activity. the role of transtympanic infusions of n-acetylcysteine was examined in a cohort of patients treated with cisplatin-based regimens. ## Patients and methods: Twenty cisplatin-treated patients were subjected, under local anesthesia, to transtympanic n-acetylcysteine (10%) infusions in 1 ear, during the hydration procedure preceding intravenous effusion of cisplatin. the contralateral ear was used as control. the number of transtympanic infusions was respective to the number of administered cycles. hearing acuity was evaluated before each cycle with pure tone audiometry by an audiologist blinded to the treated ear. ## Results: A total of 84 transtympanic infusions were performed. in treated ears, no significant changes in auditory thresholds were recorded. in the control ears cisplatin induced a significant decrease of auditory thresholds at the 8000 hz frequency band (p=0.008). at the same frequency (8000 hz), the changes in auditory thresho
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- Author
- Maria G. Riga; Leonidas Chelis; Stylianos Kakolyris; Stergios Papadopoulos; Sofia Stathakidou; Eleni Chamalidou; Nikolaos Xenidis; Kyriakos Amarantidis; Prokopios Dimopoulos; Vasilios Danielides
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2013
- Language
- EN
- Field
- Medicine (Health Sciences)