Can I read Target of rapamycin controls hyphal growth and pathogenicity through FoTIP4 in Fusarium oxysporum on EtoBox?

Target of rapamycin controls hyphal growth and pathogenicity through FoTIP4 in Fusarium oxysporum by Linxuan Li; Tingting Zhu; Yun Song; Xiumei Luo; Raju Datla; Maozhi Ren is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Target of rapamycin controls hyphal growth and pathogenicity through FoTIP4 in Fusarium oxysporum about?

## Abstract Fusarium oxysporum is the causal agent of the devastating Fusarium wilt by invading and colonizing the vascular system in various plants, resulting in substantial economic losses worldwide. Target of rapamycin (TOR) is a central regulator that controls intracellular metabolism, cell growth, and stress responses in eukaryotes, but little is known about TOR signalling in F. oxysporum. In this study, we identified conserved FoTOR signalling pathway components including FoTORC1 and FoTORC2. Pharmacological assays showed that F. oxysporum is hypersensitive to rapamycin in the presence of FoFKBP12 while the deletion mutant strain ΔFofkbp12 is insensitive to rapamycin. Transcriptomic data indicated that FoTOR signalling controls multiple metabolic processes including ribosome biogenesis and cell wall‐degrading enzymes (CWDEs). Genetic analysis revealed that FoTOR1 interacting protein 4 (FoTIP4) acts as a new component of FoTOR signalling to regulate hyphal growth and pathogenicity of F. oxysporum. Importantly, transcript levels of genes associated with ribosome biogenesis and CWDEs were dramatically downregulated in the ΔFotip4 mutant strain. Electrophoretic mobility shift ass

Who reads Target of rapamycin controls hyphal growth and pathogenicity through FoTIP4 in Fusarium oxysporum?

Author

Linxuan Li; Tingting Zhu; Yun Song; Xiumei Luo; Raju Datla; Maozhi Ren

Publisher

Wiley

Published

2021

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)