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Late Cardiotoxicity After Treatment for a Malignant Bone Tumor by Postma, A.; Bink-Boelkens, M.T.E.; Beaufort-Krol, G.C.M.; Kengen, R.A.M.; Elzenga, N.J.; Schasfoort-van Leeuwen, M.J.M.; Schraffordt Koops, H.; Kamps, W.A. is a Medicine article available to read on EtoBox.
What is Late Cardiotoxicity After Treatment for a Malignant Bone Tumor about?
Cardiac function was assessed in longterm survivors of malignant bone tumors who were treated according to Rosen's T, or T I , protocol, both including doxorubicin. Thirty-one patients, ages 10-45 years (median age 17.8 years) were evaluated 2.3-14.1 years (median 8.9 years) following completion of treatment. Cumulative doses of doxorubicin were 225-550 mg/m2 (median dose 360). The evaluation consisted of a history, physical examination, electrocardiogram (ECG), signal averaged ECG, 24-hour ambulatory ECG, echocardiography and radionuclide angiography. Eighteen of 31 (58%) patients showed cardiac toxicity, defined as having one or more of the following abnormalities: late potentials, complex ventricular arrhythmias, left ventricular dilatation, de-creased shortening fraction, or decreased ejection fraction. The incidence of cardiac abnormalities increased with length of follow-up ( P s .05). No correlation could be demonstrated between cumulative dose of doxorubicin and cardiac status, except for heart rate variability. When adjusted to body surface area, the left ventricular posterior wall thickness (LVPW index) was decreased in all patients. The incidence of doxorubicininduced ca
Who reads Late Cardiotoxicity After Treatment for a Malignant Bone Tumor?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Postma, A.; Bink-Boelkens, M.T.E.; Beaufort-Krol, G.C.M.; Kengen, R.A.M.; Elzenga, N.J.; Schasfoort-van Leeuwen, M.J.M.; Schraffordt Koops, H.; Kamps, W.A.
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0098-1532)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)