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Spironolactone Is Effective in Treating Hypokalemia Among Peritoneal Dialysis Patients by Amit Langote; Swapnil Hiremath; Marcel Ruzicka; Brendan B. McCormick is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background: Hypokalemia is common in peritoneal dialysis (pd) patients and is associated with increased cardiovascular and all-cause mortality. the management approach for such patients routinely includes spironolactone at our centre. we undertook this study to assess the efficacy of spironolactone for the treatment of hypokalemia in pd patients. ## Methods: Retrospective chart review of pd patients at a single centre. serum potassium was compared prior to initiation of spironolactone and two months afterwards. indication for spironolactone and changes in blood pressure (bp), weight, and serum creatinine were also recorded. ## Results: The chart review identified 53 patients who fit our selection criteria. the mean age was 64 +/- 15 years and the majority was treated with continuous cyclic peritoneal dialysis. serum potassium rose from 3.7 +/- 0.5 to 4.2 +/- 0.5 mmol/l (p<0.0001) after 2 months with a mean dose of spironolactone of 28.5+/-15.2 mg (median dose 25 mg). a significant reduction in systolic bp was observed from 150+/- 18 to 137 +/-24 (p = 0.002); a non- significant reduction in diastolic bp was also observed. the rise in potassium was constant in the range of 0.4 to

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Author

Amit Langote; Swapnil Hiremath; Marcel Ruzicka; Brendan B. McCormick

Publisher

Public Library of Science (PLoS)

Published

2017

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)