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Modeling the Dynamics of Bivalent Histone Modifications by Ku, Wai Lim; Girvan, Michelle; Yuan, Guo-Cheng; Sorrentino, Francesco; Ott, Edward is a scholarly article available to read on EtoBox.

What is Modeling the Dynamics of Bivalent Histone Modifications about?

Epigenetic modifications to histones may promote either activation or repression of the transcription of nearby genes. Recent experimental studies show that the promoters of many lineage-control genes in stem cells have "bivalent domains" in which the nucleosomes contain both active (H3K4me3) and repressive (H3K27me3) marks. It is generally agreed that bivalent domains play an important role in stem cell differentiation, but the underlying mechanisms remain unclear. Here we formulate a mathematical model to investigate the dynamic properties of histone modification patterns. We then illustrate that our modeling framework can be used to capture key features of experimentally observed combinatorial chromatin states.

Author

Ku, Wai Lim; Girvan, Michelle; Yuan, Guo-Cheng; Sorrentino, Francesco; Ott, Edward

Published

2013

Language

EN