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Effects of Carbamazepine on Hippocampal Serotonergic System by Motohiro Okada; Takayuki Hirano; Kazuhisa Mizuno; Yuko Kawata; Kazumaru Wada; Takuya Murakami; Hiroichi Tasaki; Sunano Kaneko is a Medicine article available to read on EtoBox.

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To establish the mechanism of action of the antiepileptic and psychotropic effects of carbamazepine (CBZ), its effects on serotonin (5-HT) transmission, metabolism and re-uptake activity in the rat hippocampus were studied. After acute and chronic administrations of 25 mg/kg CBZ, the plasma concentration of CBZ was found to be within the therapeutic range, whereas both acute and chronic administrations of 50 and 100 mg/kg CBZ resulted in a supratherapeutic plasma concentration. Acute administration of the therapeutic dose of CBZ resulted in an increase in the hippocampal extracellular and total level of 5-HT, its metabolite, 5-hydroxydoleacetic acid (5-HIAA) and its precursor, 5-hydroxytryptophan (5-HTP). The acute administration of 50 mg/kg CBZ resulted in an increase in the hippocampal levels of extracellular 5-HT and 5-HIAA as well as in the total levels of 5-HTP, whereas hippocampal levels of extracellular 5-HTP, total 5-HT and 5-HIAA remained unaffected. CBZ at a dose of 100 mg/kg decreased the levels of all of these substances. After chronic administration, 25 mg/kg/day CBZ increased hippocampal total levels of 5-HT, 5-HTP and 5-HIAA, whereas 100 mg/kg/day CBZ decreased all o

Who reads Effects of Carbamazepine on Hippocampal Serotonergic System?

Author

Motohiro Okada; Takayuki Hirano; Kazuhisa Mizuno; Yuko Kawata; Kazumaru Wada; Takuya Murakami; Hiroichi Tasaki; Sunano Kaneko

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0920-1211)

Published

1998

Language

EN

Field

Medicine (Health Sciences)