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Biomarker Acquisition and Quality Control for Multi-Site Studies: The Autism Biomarkers Consortium for Clinical Trials by Sara Jane Webb; Frederick Shic; Michael Murias; Catherine A. Sugar; Adam J. Naples; Erin Barney; Heather Borland; Gerhard Hellemann; Scott Johnson; Minah Kim; April R. Levin; Maura Sabatos-DeVito; Megha Santhosh; Damla Senturk; James Dziura; Raphael A. Bernier; Katarzyna Chawarska; Geraldine Dawson; Susan Faja; Shafali Jeste; James McPartland; the Autism Biomarkers Consortium for Clinical Trials is a Neuroscience article available to read on EtoBox.

What is Biomarker Acquisition and Quality Control for Multi-Site Studies: The Autism Biomarkers Consortium for Clinical Trials about?

The objective of the Autism Biomarkers Consortium for Clinical Trials (ABC-CT) is to evaluate a set of lab-based behavioral video tracking (VT), electroencephalography (EEG), and eye tracking (ET) measures for use in clinical trials with children with autism spectrum disorder (ASD). Within the larger organizational structure of the ABC-CT, the Data Acquisition and Analytic Core (DAAC) oversees the standardization of VT, EEG, and ET data acquisition, data processing, and data analysis. This includes designing and documenting data acquisition and analytic protocols and manuals; facilitating site training in acquisition; data acquisition quality control (QC); derivation and validation of dependent variables (DVs); and analytic deliverables including preparation of data for submission to the National Database for Autism Research (NDAR). To oversee consistent application of scientific standards and methodological rigor for data acquisition, processing, and analytics, we developed standard operating procedures that reflect the logistical needs of multi-site research, and the need for well-articulated, transparent processes that can be implemented in future clinical trials. This report de

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Author

Sara Jane Webb; Frederick Shic; Michael Murias; Catherine A. Sugar; Adam J. Naples; Erin Barney; Heather Borland; Gerhard Hellemann; Scott Johnson; Minah Kim; April R. Levin; Maura Sabatos-DeVito; Megha Santhosh; Damla Senturk; James Dziura; Raphael A. Bernier; Katarzyna Chawarska; Geraldine Dawson; Susan Faja; Shafali Jeste; James McPartland; the Autism Biomarkers Consortium for Clinical Trials

Publisher

Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2007- (ISSN 1662-5145)

Published

2020

Language

EN

Field

Neuroscience (Life Sciences)