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Cathepsin B Drives Trypsin Activity in Pancreatitis by jidom53807 is a document available to read on EtoBox.
This study investigates the role of cathepsin B (CTSB) and trypsinogen autoactivation in cerulein-induced pancreatitis in mice. The findings indicate that intrapancreatic trypsin activity is exclusively generated by CTSB, with no contribution from autoactivation, and that this trypsin activity does not correlate with the severity of pancreatitis. The results suggest that CTSB-elicited trypsin is not necessary for the onset or severity of pancreatitis, contrasting with the pathogenic role of trypsin from aut
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- jidom53807
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- EN