Can I read FAM83B promotes the invasion of primary lung adenocarcinoma via PI3K/AKT/NF-κB pathway on EtoBox?

FAM83B promotes the invasion of primary lung adenocarcinoma via PI3K/AKT/NF-κB pathway by Jing Zhang; Jiajia Wang; Ke Yue; Panpan Li; Wenping Shen; Xiaowen Qiao; Yan Wang; Xiaojuan Wu is a Medicine article available to read on EtoBox.

What is FAM83B promotes the invasion of primary lung adenocarcinoma via PI3K/AKT/NF-κB pathway about?

## Abstract ## Objects The family with sequence similarity 83B (FAM83B) is one of the markers for poor prognosis in several carcinomas, but the expression and the mechanism resulted in malignant phenotype in lung adenocarcinoma (LUAD) remain to be elucidated. ## Methods Data of RNA-seq in LUAD were downloaded from the cancer genome atlas (TCGA) database for differential expression and survival analysis, and immunohistochemistry was employed to analyze the protein expression of FAM83B in 126 cases of primary LUAD. The LUAD cell lines were collected for the detection of the effects on migration and invasion. Then, western blot was performed to measure the expression of tissue inhibitor of metalloproteinase (TIMP)-1 and activation of PI3K/AKT/NF-κB pathway. ## Results FAM83B was overexpressed in multiple types of carcinomas; The differential expression analysis revealed that the level of FAM83B was higher in LUAD than that in para-carcinoma; The patients with overexpression of FAM83B were with shorter overall survival (OS), disease specific survival (DSS) and progress free interval (PFI); Enrichment analysis suggested it was related to the focal adhesion of LUAD. Immunohistochemistry

Who reads FAM83B promotes the invasion of primary lung adenocarcinoma via PI3K/AKT/NF-κB pathway?

Author

Jing Zhang; Jiajia Wang; Ke Yue; Panpan Li; Wenping Shen; Xiaowen Qiao; Yan Wang; Xiaojuan Wu

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)