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Synthesis and Biological Activity of Flavanone Derivatives by Lei Shi; Xiu E Feng; Jing Rong Cui; Lian Hua Fang; Guan Hua Du; Qing Shan Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Synthesis and Biological Activity of Flavanone Derivatives about?

A series of new flavanone derivatives of farrerol was synthesized by a convenient method. The in vitro anti-tumor activity of these compounds was evaluated against human Bel-7402, HL-60, BGC-823 and KB cell lines, the protein tyrosine kinase (PTK) inhibitor activity was also tested. Their cytoprotective activity was tested using hydrogen peroxide (H2O2)-induced injury in human umbilical vein endothelial cells. Their in vitro anti-atherosclerosis activity was tested on vascular smooth muscle cells by the MTT method using tetrandrine as a positive contrast drug. The structures of all compounds synthesized were confirmed by 1H, 13C NMR and ESI-MS. Most of the compounds exhibited good pharmacological activity and the preliminary structure-activity relationships were described.

Who reads Synthesis and Biological Activity of Flavanone Derivatives?

Author

Lei Shi; Xiu E Feng; Jing Rong Cui; Lian Hua Fang; Guan Hua Du; Qing Shan Li

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)