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Association of Enlarged Perivascular Spaces With Amyloid Burden and Cognitive Decline in Alzheimer Disease Continuum by Seong Ho Jeong; Jungho Cha; Mincheol Park; Jin Ho Jung; Byoung Seok Ye; Young H. Sohn; Seok Jong Chung; Phil Hyu Lee is a Medicine article available to read on EtoBox.
What is Association of Enlarged Perivascular Spaces With Amyloid Burden and Cognitive Decline in Alzheimer Disease Continuum about?
## Background and Objectives To investigate the effects of enlarged perivascular space (EPVS) on amyloid burden and cognitive function in Alzheimer disease (AD) continuum. ## Methods We retrospectively reviewed 208 patients with AD across the cognitive continuum (preclinical, prodromal, and AD dementia) who showed amyloid deposition on ^18^F-florbetaben PET scans and 82 healthy controls. EPVSs were counted for each patient in the basal ganglia (BG), centrum semiovale (CSO), and hippocampus (HP) on axial T2-weighted images. Patients were then classified according to the number of EPVSs into the EPVS+ (>10 EPVSs) and EPVS– (0–10 EPVSs) groups for the BG and CSO, respectively. In terms of HP-EPVS, equal or more than 7 EPVSs on bilateral hemisphere were regarded as the presence of HP-EPVS. After adjusting for markers of small vessel disease (SVD), multiple linear regression analyses were performed to determine the intergroup differences in global and regional amyloid deposition and cognitive function at the time of diagnosis of AD continuum. A linear mixed model was used to assess the effects of EPVSs on the longitudinal changes in the Mini-Mental State Examination (MMSE) scores. ## Re
Who reads Association of Enlarged Perivascular Spaces With Amyloid Burden and Cognitive Decline in Alzheimer Disease Continuum?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Seong Ho Jeong; Jungho Cha; Mincheol Park; Jin Ho Jung; Byoung Seok Ye; Young H. Sohn; Seok Jong Chung; Phil Hyu Lee
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)