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Can I read Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters on EtoBox?
Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters by Richard Frenette; Marc Blouin; Christine Brideau; Nathalie Chauret; Yves Ducharme; Richard W. Friesen; Pierre Hamel; Tom R. Jones; France Laliberté; Chun Li; Paul Masson; Malia McAuliffe; Yves Girard is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters about?
A detailed SAR study directed toward the optimization of pharmacokinetic parameters for analogues of L-791,943 is reported. The introduction of a soft metabolic site on this structure permitted the identification of L-826,141 as a potent phosphodiesterase type 4 (PDE4) inhibitor that is well absorbed and that presents a shorter half-life than L-791,943 in a variety of animal species. The efficacy of L-826,141 is also demonstrated in different in vivo models.
Who reads Substituted 4-(2,2-diphenylethyl)pyridine-N-oxides as phosphodiesterase-4 inhibitors: SAR study directed toward the improvement of pharmacokinetic parameters?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Richard Frenette; Marc Blouin; Christine Brideau; Nathalie Chauret; Yves Ducharme; Richard W. Friesen; Pierre Hamel; Tom R. Jones; France Laliberté; Chun Li; Paul Masson; Malia McAuliffe; Yves Girard
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2002
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)