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Can I read Calponin 1 Increases Cancer-associated Fibroblasts-mediated Matrix Stiffness to Promote Chemoresistance in Gastric Cancer on EtoBox?
Calponin 1 Increases Cancer-associated Fibroblasts-mediated Matrix Stiffness to Promote Chemoresistance in Gastric Cancer by Yifan Lu; Zhijian Jin; Junyi Hou; Xiongyan Wu; Zhenjia Yu; Lizhong Yao; Tao Pan; Xinyu Chang; Beiqin Yu; Jianfang Li; Chen Li; Min Yan; Chao Yan; Zhenggang Zhu; Bingya Liu; Liping Su is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Calponin 1 Increases Cancer-associated Fibroblasts-mediated Matrix Stiffness to Promote Chemoresistance in Gastric Cancer about?
The mechanical microenvironment regulated by cancer-associated fibroblasts (CAFs) influence tumor progression. Chemotherapeutic interventions including 5-Fluorouracil (5-Fu) are commonly used for primary treatment of patients with advanced gastric cancer (GC), and the development of acquired resistance to 5-Fu limits the clinical efficacy of these chemotherapies. However, if and how the interplay between CAFs and the mechanical microenvironment regulates GC response to 5-Fu is poorly understood. In this study, we demonstrate that high-level expression of calponin 1(CNN1) in gastric CAFs predicts poor clinical outcomes of GC patients, especially for those treated with 5-Fu. CNN1 knockdown in CAFs improves the effectiveness of 5-Fu in reducing tumor growth in a mouse GC model and confers increased sensitivity to 5-Fu in a 3D culture system. Furthermore, CNN1 knockdown impairs CAF contraction and reduces matrix stiffness without affecting the expression of matrix proteins. Mechanistically, CNN1 interacts with PDZ and LIM Domain 7 (PDLIM7) and prevents its degradation by the E3 ubiquitin ligase NEDD4-1, which leads to activation of the ROCK1/MLC pathway. The increased matrix stiffness,
Who reads Calponin 1 Increases Cancer-associated Fibroblasts-mediated Matrix Stiffness to Promote Chemoresistance in Gastric Cancer?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yifan Lu; Zhijian Jin; Junyi Hou; Xiongyan Wu; Zhenjia Yu; Lizhong Yao; Tao Pan; Xinyu Chang; Beiqin Yu; Jianfang Li; Chen Li; Min Yan; Chao Yan; Zhenggang Zhu; Bingya Liu; Liping Su
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)