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Exposure to multiple toxic metals and polycystic ovary syndrome risk: Endocrine disrupting effect from As, Pb and Ba by Chunmei Liang; Zhikang Zhang; Yu Cao; Jieyu Wang; Lingchao Shen; Tingting Jiang; Danyang Li; Weiwei Zou; Kai Zong; Dan Liang; Xiaofeng Xu; Yajing Liu; Fangbiao Tao; Guiying Luo; Dongmei Ji; Yunxia Cao is a Environmental Science article available to read on EtoBox.

What is Exposure to multiple toxic metals and polycystic ovary syndrome risk: Endocrine disrupting effect from As, Pb and Ba about?

## Background: Polycystic ovarian syndrome (pcos) affects 5 % ~ 20 % of women of reproductive age and is a serious health problem. whether exposure to lead (pb), mercury (hg), arsenic (as), barium (ba) or (cadmium) cd is associated with an increased risk of pcos, particularly their joint effect as well as their association with the clinical phenotype of pcos is limited and unclear. ## Objectives: We aimed to explore the associations of the blood pb, hg, as, ba and cd levels and risk of pcos in chinese women of reproductive age. ## Methods: A case-control study was used and included 369 women with pcos and 441 controls. the levels of pb, hg, as, ba and cd were measured in fasting blood samples collected on the 2nd or 3rd day of menstruation or vaginal bleeding after drug withdrawal; basal sex hormone levels, fasting glucose and fasting insulin were measured simultaneously. unconditional logistic regression models were used to assess the relationship of the blood pb, hg, as, ba or cd levels with pcos risk. bayesian kernel machine regression (bkmr) was used to assess the joint effect of pb, hg, as, ba and cd on pcos risk and estimate which metal or metals contributed most to the assoc

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Author

Chunmei Liang; Zhikang Zhang; Yu Cao; Jieyu Wang; Lingchao Shen; Tingting Jiang; Danyang Li; Weiwei Zou; Kai Zong; Dan Liang; Xiaofeng Xu; Yajing Liu; Fangbiao Tao; Guiying Luo; Dongmei Ji; Yunxia Cao

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Environmental Science (Physical Sciences)